Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured affiliate professor within the Division of Molecular Pharmacology and Physiology on the College of South Florida Morsani School of Medication and a Visiting Senior Analysis Scientist on the Institute for Human and Machine Cognition.
He teaches medical neuroscience, physiology, diet, and neuropharmacology, and his analysis focuses on the event and testing of dietary methods and metabolic-based therapies for neurological issues, most cancers, and human efficiency optimization. His work spans each primary science and human medical trials.
He has a robust private curiosity in environmental drugs and enhancing the security and resilience of army personnel and astronauts. On this capability, he served as a analysis investigator and crew member on NASA’s Excessive Setting Mission Operations. His analysis has been supported by the Workplace of Naval Analysis, the Division of Protection, the Nationwide Institutes of Well being, personal organizations, and nonprofit foundations.
He earned his B.S. in Dietary Science and Organic Sciences from Rutgers College in 1998, adopted by a predoctoral fellowship in Neuroscience and Physiology at Rutgers and the College of Medication and Dentistry of New Jersey. He then accomplished postdoctoral coaching in Neuroscience at Wright State College’s Boonshoft College of Medication in 2004 and at College of South Florida Morsani School of Medication in 2006.
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The way to Use Ketosis for Enhanced Temper, Cognition, and Lengthy-Time period Mind Safety — A Sensible and Tactical Information with Dr. Dominic D’Agostino (Plus: Deconstructing Tim’s Newest Keto Experiment)
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Transcripts
SELECTED LINKS FROM THE EPISODE
- Join with Dominic D’Agostino:
KetoNutrition.org | Fb | Twitter | College of South Florida
Dr. Dominic D’Agostino’s Previous Appearances
Gadgets & Wearables
Merchandise, Manufacturers, & Companies
Books
Lab Exams, Biomarkers, & Metrics
Dietary supplements, Compounds, and Phrases
Individuals
Organizations & Establishments
TIMESTAMPS
- [00:00:00] Begin.
- [00:04:37] Ketosis advantages: Quieting the thoughts, GABA elevation, metabolic psychiatry.
- [00:09:24] My Lyme illness story: Pseudo-dementia reversed in 3-4 days of ketosis.
- [00:13:50] Spirochetes are glycolytic: Starve the bug, increase the immune response.
- [00:19:20] Ketosis and most cancers: Slowing glycolytic tumors, enhancing customary care.
- [00:20:50] My 18-day keto experiment: Temper stabilization, Alzheimer’s prevention hopes.
- [00:23:19] Metabolic reminiscence: Carryover results and Valter Longo’s fasting mimicking analysis.
- [00:27:11] Intermittent fasting as keto on-ramp: My 2-8 p.m. consuming window.
- [00:29:15] Dom’s funds keto meal: Canned mackerel, MCT oil, apple cider vinegar.
- [00:33:28] My ketone measurement paradox: Feeling sharp at 0.2 mM readings.
- [00:36:56] The carburetor analogy: Ketone manufacturing vs. utilization defined.
- [00:38:43] Breath ketones vs. blood ketones: Higher indicator in caloric deficit.
- [00:39:47] Gluconeogenesis fears: Fats, fiber, and salt to gradual protein absorption.
- [00:45:25] The bunless double cheeseburger query: 80 grams of protein in a single sitting.
- [00:49:03] Put up-meal strolling and GLUT4 activation: Timing your glucose disposal.
- [00:51:02] CGM and ketone monitor limitations: When your gadgets gaslight you.
- [00:58:05] Rabbit hunger and protein-veggie days: Why your physique gained’t bankroll its personal ketosis.
- [01:05:44] Alzheimer’s prevention: Biomarkers, B12, hsCRP, and metabolic well being.
- [01:09:40] My household historical past: Letrozole, metabolic dysfunction, and fast cognitive decline.
- [01:13:17] Minimal efficient dose: 80% of advantages from low-carb Mediterranean.
- [01:18:56] One week monthly protocol: Aggressive calorie reduce to ramp ketones.
- [01:23:12] GKI candy spot: Goal 1-4, purpose for 1-2 throughout intensive weeks.
- [01:36:22] Exogenous ketones 101: Palatability, tolerability, pharmacokinetics, toxicity.
- [01:39:21] 1,3-Butanediol warnings: Liver toxicity, NAD depletion, dependency threat.
- [01:54:22] Intermittent fasting vs. ketogenic breakfast.
- [01:59:09] My unintended intoxication story.
- [02:03:23] Dr. Veech tribute: Scholar of Hans Krebs, ketone ester pioneer.
- [02:05:08] Fiber on keto: Wild blueberries, broccoli, apples, walnuts.
- [02:09:58] The contaminated gummies incident: Dom’s forensic investigation underway.
- [02:13:08] Because of Dr. Boz and Medifoodz.
- [02:16:19] Parting ideas.
DOMINIC D’AGOSTINO QUOTES FROM THE INTERVIEW
“We all know that being in a state of ketosis actually quiets the thoughts … and that, I feel, actually echoes its broad software for metabolic psychiatry, which is all the things from main despair to bipolar, to schizophrenia, to anxiousness issues, to anorexia nervosa.”
— Dominic D’Agostino
“Very like muscle reminiscence, I feel there’s a metabolic reminiscence. So the extra you keep in ketosis, the simpler it will get, and the extra advantages you derive from it, and the extra that you simply shift your physique to being extra fats tailored — identical to you may construct your VO2.”
— Dominic D’Agostino
“[The ketogenic diet] shouldn’t be a treatment for most cancers, and I cringe when individuals speak about that on-line. [But] it does gradual it down, particularly if it’s extremely glycolytic, which 80% of cancers are.”
— Dominic D’Agostino
“I feel you will get 80% of the advantages [of ketosis] with a low-carb weight-reduction plan — low-carb that means 100 grams a day, simply fibrous, non-starch, non-sugar carbs, low-carb Mediterranean, if you wish to name it that.”
— Dominic D’Agostino
“Resistance train, I’m a bit biased in direction of that, however muscle is like an endocrine organ that produces hormones and numerous molecules which are neuroprotective and muscle is tightly linked to mind dimension and, after all, your waist and your visceral fats.”
— Dominic D’Agostino
“My concern … is that I do know there’s older individuals on the market with dementia, maybe Alzheimer’s illness, that in the event that they’re consuming 1,3-Butanediol as a ketogenic complement, it’s going to make you dizzy. It’s going to lower your stability, it’s going to make you probably fall, break your hip.”
— Dominic D’Agostino
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Wish to hear the final time Dominic D’Agostino was on the podcast? Take heed to our dialog right here, by which we mentioned ketones and neuroprotection, sardine fasting, glucose ketone index for autophagy monitoring, ldl cholesterol hyperabsorption, melatonin myths, metabolic psychiatry, hyperbaric oxygen remedy, metformin versus berberine, and way more.
