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Dr. Dominic D’Agostino — All Issues Ketones, Easy methods to Shield the Mind and Enhance Cognition, Sardine Fasting, Weight-reduction plan Guidelines, Revisiting Metformin and Melatonin, and Extra (#825)

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Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured affiliate professor within the Division of Molecular Pharmacology and Physiology on the College of South Florida Morsani Faculty of Drugs and a Visiting Senior Analysis Scientist on the Institute for Human and Machine Cognition.

He teaches medical neuroscience, physiology, diet, and neuropharmacology, and his analysis focuses on the event and testing of dietary methods and metabolic-based therapies for neurological issues, most cancers, and human efficiency optimization. His work spans each fundamental science and human scientific trials.

He has a powerful private curiosity in environmental medication and enhancing the protection and resilience of army personnel and astronauts. On this capability, he served as a analysis investigator and crew member on NASA’s Excessive Atmosphere Mission Operations. His analysis has been supported by the Workplace of Naval Analysis, the Division of Protection, the Nationwide Institutes of Well being, non-public organizations, and nonprofit foundations.

He earned his B.S. in Dietary Science and Organic Sciences from Rutgers College in 1998, adopted by a predoctoral fellowship in Neuroscience and Physiology at Rutgers and the College of Drugs and Dentistry of New Jersey. He then accomplished postdoctoral coaching in Neuroscience at Wright State College’s Boonshoft Faculty of Drugs in 2004 and at College of South Florida Morsani Faculty of Drugs in 2006.

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Dr. Dominic D’Agostino — All Issues Ketones, Easy methods to Shield the Mind and Enhance Cognition, Sardine Fasting, Weight-reduction plan Guidelines, Revisiting Metformin and Melatonin, and Extra

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SELECTED LINKS FROM THE EPISODE

  • Join with Dr. Dominic D’Agostino:

KetoNutrition.org | Fb | Twitter | College of South Florida

Dr. Dominic D’Agostino’s Previous Appearances

Ideas & Concepts

  • APOE3/4 Genotype: A genetic variant the place people carry one copy every of the APOE3 and APOE4 alleles, related to reasonably elevated danger of Alzheimer’s illness in comparison with APOE3/3 however decrease danger than APOE4/4.
  • Sort 3 Diabetes: A time period used to explain Alzheimer’s illness as a type of insulin resistance and insulin deficiency that happens particularly within the mind, characterised by impaired neuronal glucose metabolism.
  • The 4 Horsemen of Power Illness: The 4 pillars of power illness, in accordance with Dr. Peter Attia.
  • Glucose Hypometabolism: A state the place the mind’s means to make use of glucose for vitality is impaired, typically occurring greater than 10 years earlier than the onset of Alzheimer’s illness signs and regarded a key characteristic of neurodegeneration.
  • Neuroinflammation: Irritation of nervous tissue involving activation of microglia and astrocytes, thought-about a significant driver of neurodegenerative ailments together with Alzheimer’s, Parkinson’s, and a number of sclerosis.
  • Ketogenic Weight-reduction plan: A really low-carbohydrate (usually below 50g per day), high-fat weight loss program initially developed at Mayo Clinic within the Twenties to deal with epilepsy, which forces the physique to provide ketones for gasoline as a substitute of utilizing glucose.
  • Mediterranean-Type Low-Carb Weight-reduction plan: A modified model of the normal Mediterranean weight loss program that reduces carbohydrate consumption whereas emphasizing greens, fish, olive oil, nuts, and wholesome fat to help weight reduction and blood sugar management.
  • Exogenous Ketones: Ketone our bodies (primarily beta-hydroxybutyrate) which might be consumed by dietary dietary supplements within the type of ketone salts, esters, or precursor compounds, permitting for fast elevation of blood ketones with out dietary restriction.
  • Ketone Monoester vs. Diester vs. Salts: Totally different types of exogenous ketone dietary supplements the place monoesters present essentially the most environment friendly ketone elevation, diesters are bonds between two ketone molecules, and salts mix ketones with minerals like sodium or potassium.
  • Glucose Ketone Index (GKI): A ratio calculated by dividing blood glucose ranges by ketone ranges, used as a biomarker for metabolic well being and the depth of ketosis, with decrease values indicating higher metabolic flexibility.
  • Fasting and “Sardine Fasting”: Abstaining from meals for therapeutic advantages, with “sardine fasting” referring to a modified fasting strategy the place solely sardines are consumed, offering protein whereas sustaining some advantages of fasting.
  • Autophagy: The physique’s mobile recycling strategy of cleansing out broken organelles and proteins to regenerate newer, more healthy mobile elements, enhanced during times of fasting and ketosis.
  • Most cancers Cachexia: A fancy metabolic syndrome characterised by extreme lack of muscle mass and physique weight, typically accompanied by anemia, weak point, and lack of urge for food in most cancers sufferers.
  • Metabolic Psychiatry: An rising area that makes use of metabolic interventions, notably ketogenic diets and exogenous ketones, to deal with psychological well being situations by addressing underlying metabolic dysfunction within the mind.
  • NLRP3 Inflammasome: A multiprotein advanced in immune cells that acts as a mobile sensor and triggers inflammatory responses, enjoying a vital position in innate immunity and implicated in varied neurodegenerative ailments.
  • Metabolic Management of Epigenetic Regulation: The idea that metabolites like beta-hydroxybutyrate can immediately affect gene expression by appearing as signaling molecules and histone deacetylase inhibitors, affecting mobile perform and well being.
  • Redox Stress: An imbalance within the mobile ratio of NAD+ to NADH that may impair mitochondrial perform and vitality manufacturing, typically related to ageing and metabolic dysfunction.
  • Hyperbaric Oxygen Remedy (HBOT): A medical therapy involving respiration pure oxygen in a pressurized chamber at 1.5 to three occasions regular atmospheric strain, used to reinforce therapeutic and deal with varied situations together with wound therapeutic and carbon monoxide poisoning.
  • Lipid Power Mannequin: A metabolic mannequin explaining how LDL ldl cholesterol and ApoB particles could be elevated on low-carbohydrate diets as they perform as transport autos for mobilized fatty acids used for vitality manufacturing.
  • SARM (Selective Androgen Receptor Modulator): A category of therapeutic compounds designed to selectively bind to androgen receptors in particular tissues, probably providing the muscle-building advantages of anabolic steroids with diminished androgenic unwanted side effects.

Substances & Medicine

  • Beta-Hydroxybutyrate (BHB): The first ketone physique produced throughout fats metabolism and ketosis, used in its place vitality supply for the mind and physique.
  • 1,3-Butanediol: A ketone precursor and alcohol compound that’s metabolized into beta-hydroxybutyrate (BHB) within the liver.
  • MCT Oil (Medium-Chain Triglyceride): A kind of saturated fats that’s readily absorbed and transformed into ketones, generally utilized in ketogenic diets.
  • Creatine Monohydrate: A complement that helps regenerate ATP in muscular tissues, recognized for bettering train efficiency, power, and probably cognitive perform.
  • Lipopolysaccharide (LPS): A element of gram-negative bacterial cell partitions utilized in analysis to induce systemic irritation and examine immune responses.
  • Ezetimibe (Zetia): A prescription treatment that lowers ldl cholesterol by inhibiting its absorption within the small gut.
  • Rapamycin: An immunosuppressive drug initially used to forestall organ rejection that has gained consideration for potential anti-aging and longevity results.
  • Metformin: A primary-line treatment for kind 2 diabetes that lowers blood glucose ranges and has potential advantages for longevity and metabolic well being.
  • Berberine/Dihydroberberine: Plant-derived alkaloid compounds with glucose-lowering results just like metformin, used for metabolic well being help.
  • GLP-1 Agonists: A category of diabetes drugs that mimic incretin hormones to manage blood sugar and promote weight reduction, together with medication like semaglutide and tirzepatide.
  • SGLT-2 Inhibitors: A category of diabetes drugs that decrease blood sugar by stopping glucose reabsorption within the kidneys, inflicting extra glucose to be excreted in urine.
  • NAD Dietary supplements: Dietary supplements like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) designed to spice up mobile NAD+ ranges for potential anti-aging advantages.
  • Idebenone / CoQ10 / Ubiquinol: Antioxidant compounds that help mitochondrial vitality manufacturing and mobile well being, with CoQ10 being important for ATP synthesis.
  • GABA / Phenibut: Gamma-aminobutyric acid and associated compounds which have calming, inhibitory results on the central nervous system.
  • Diphenhydramine (Benadryl): An over-the-counter antihistamine generally used for allergic reactions that causes drowsiness and is typically used as a sleep assist.
  • Melatonin: A hormone naturally produced by the pineal gland that regulates the sleep-wake cycle and is usually used as a sleep complement.
  • Ostarine: A selective androgen receptor modulator (SARM) that selectively targets muscle and bone tissue, talked about for veterinary use in analysis contexts.
  • Alpha GPC / Theanine: Nootropic compounds the place Alpha-GPC helps acetylcholine manufacturing for cognitive perform and L-theanine promotes leisure with out sedation.

Merchandise & Manufacturers

  • KetoStart (Audacious Vitamin): A ketone electrolyte complement firm based by Dr. Dominic D’Agostino’s spouse, specializing in exogenous ketone merchandise.
  • Qitone: A model that produces ketone diester powder dietary supplements for enhancing ketosis and metabolic efficiency.
  • Keto-Mojo: An organization that manufactures transportable blood glucose and ketone testing gadgets widespread amongst these following ketogenic diets.
  • Abbott Precision Xtra: A dual-purpose blood glucose and ketone monitoring system manufactured by Abbott for diabetes administration and ketosis monitoring.
  • LMNT: An electrolyte complement model that gives sugar-free, keto-friendly hydration merchandise with optimum sodium, potassium, and magnesium ratios.
  • Ranges: A metabolic well being firm that gives steady glucose screens (CGMs) paired with an app to assist customers optimize their blood sugar responses.
  • Stelo: An over-the-counter steady glucose monitor developed by Dexcom for folks with out diabetes to trace their glucose patterns.
  • GB HealthWatch: A genetic testing firm that gives personalised stories for dyslipidemia and cardiovascular danger evaluation based mostly on DNA evaluation.
  • Dry Farm Wines: A wine firm specializing in pure, low-sugar, additive-free wines which might be lab-tested for purity and decrease alcohol content material.
  • French Ladies Don’t Get Fats: The Secret of Consuming for Pleasure by Mireille Guiliano: A bestselling life-style information that reveals the “French paradox” of how French girls keep slim whereas having fun with bread, wine, and three-course meals by rules of stability, high quality over amount, and consuming for pleasure reasonably than restriction.
  • Keto Brainz: A complement model that produces MCT powder enhanced with nootropic compounds to help each ketosis and cognitive perform.
  • Nutricost / Quest: In style complement manufacturers that supply MCT powder merchandise amongst their in depth product strains.
  • Nordic Naturals: A premium omega-3 complement model recognized for high-quality fish oil merchandise with third-party purity testing and sustainable sourcing.
  • OmegaQuant: A testing firm that measures omega-3 fatty acid ranges in blood to assist people optimize their omega-3 standing and cardiovascular well being.
  • Metabolic Thoughts: An academic platform from the Baszucki Group that focuses on metabolic approaches to psychological well being and psychiatric situations.
  • MetPsy: An app presently in improvement designed to offer metabolic remedy teaching and help for psychological well being purposes.

Establishments

  • NIH (Nationwide Institutes of Well being): The first company of america authorities chargeable for biomedical and public well being analysis.
  • USF (College of South Florida): Public analysis college in Tampa the place Dr. D’Agostino is a professor.
  • Byrd Alzheimer’s Middle: Analysis institute at USF Well being devoted to Alzheimer’s illness prevention, therapy and treatment the place Dr. D’Agostino’s spouse labored.
  • Buck Institute for Analysis on Ageing: Unbiased biomedical analysis institute in California centered on extending wholesome years of life.
  • Harvard College: Non-public Ivy League analysis college in Cambridge, Massachusetts the place Chris Palmer and Georgia Ede are affiliated.
  • Moffitt Most cancers Middle: Nationwide Most cancers Institute-designated complete most cancers heart in Tampa collaborating with Dr. D’Agostino.
  • Stanford College: Non-public analysis college in California the place Shebani Sethi is affiliated.
  • Oxford College: Prestigious collegiate analysis college in England the place Dr. Ally Houston is affiliated.
  • Northwestern College: Non-public analysis college in Illinois the place Dr. Nav Chandel conducts analysis.
  • College of Edinburgh: Public analysis college in Scotland the place Dr. Iain Campbell conducts analysis.
  • Yale College: Non-public Ivy League analysis college in Connecticut the place Dr. Deep Dixit is a researcher.
  • Genentech: American biotechnology company and subsidiary of Roche, pioneering in recombinant DNA expertise.
  • Metro Worldwide Biotech: Medical-stage pharmaceutical firm creating NAD+ precursors and therapeutics like MIB-626.

Related Sources & Analysis

Folks

SHOW NOTES

  • [00:00:00] Begin.
  • [00:14:43] Why I’m all in favour of ketogenic methods for neurodegenerative prevention.
  • [00:16:18] Mary and Steve Newport’s ketone-linked momentary cognitive enhancements.
  • [00:18:18] A mechanisms overview for Alzheimer’s/dementia.
  • [00:21:25] The immune system as longevity’s “fifth horseman” — and why metabolic management is vital.
  • [00:22:04] Easy methods to measure ketones and GKI.
  • [00:23:00] Fasting vs. ketogenic weight loss program.
  • [00:24:18] There’s nothing fishy about sardine fasting.
  • [00:28:32] My hiatal hernia discovery and elevated most cancers danger issues.
  • [00:30:04] HSCRP as a superior biomarker to LDL for cardiovascular danger.
  • [00:31:57] Glucose tolerance testing revelations and CGM significance.
  • [00:31:57] Upgrading the metabolic equipment by keto with out losing interest.
  • [00:42:07] What do do should you, like Dom and me, are among the many 30% that suffer from ldl cholesterol hyperabsorption.
  • [00:43:42] Dom’s day-to-day weight loss program routine.
  • [00:45:56] How Dom optimizes his ageing canine with ketones, SARMs, and dietary supplements.
  • [00:51:30] Supplementing for sleep disruption whereas fasting.
  • [00:55:41] Why Dom doesn’t have misgivings about melatonin.
  • [00:59:15] Shingles prevention by fasting protocols.
  • [01:00:15] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.
  • [01:03:54] Dom at 50-something: Present meal timing and composition.
  • [01:05:57] Blue zone observations: Greek and Sardinian longevity habits.
  • [01:08:16] Ketogenic weight loss program initiation suggestions: MCT, electrolytes, and fasted cardio.
  • [01:15:18] Ketone metabolic remedy for most cancers.
  • [01:18:15] The metabolic psychiatry revolution.
  • [01:22:10] The soothing results of hyperbaric oxygen and ketosis on seizure victims.
  • [01:28:27] Metformin vs. berberine.
  • [01:31:43] The low-dose neuroprotective potential of GLP-1 medication.
  • [01:34:58] NAD analysis: MIB-626 and stabilized types for mitochondrial well being.
  • [01:39:48] Idebenone, CoQ10, and the Deanna protocol for ALS.
  • [01:42:05] Dom’s complement brief record: CoQ10, creatine, ketones, vitamin D, melatonin.
  • [01:44:43] KetoNutrition.org, Metabolic Well being Summit, Audacious Vitamin, veteran-focused analysis protocols, and different parting ideas.

DR. DOMINIC D’AGOSTINO QUOTES FROM THE INTERVIEW

“I feel the fantastic thing about ketogenic [therapy] is that it’s pleiotropic, proper? Which implies it’s many mechanisms working in synergy.”

— Dr. Dominic D’Agostino

“I feel one of the simplest ways to measure to recommend you’re in autophagy is a glucose ketone index after a interval of fasting.”

— Dr. Dominic D’Agostino

“About 30 p.c of the inhabitants hyperabsorbs ldl cholesterol.”

— Dr. Dominic D’Agostino

“HSCRP is a greater indicator of heart problems than LDL ldl cholesterol. We all know that now. [No one would believe it] If somebody stated that 10 years in the past.”

— Dr. Dominic D’Agostino

“I wouldn’t go above three, most likely 1.5 to 2 millimolar vary. That appears to be a degree of ketones that safely doesn’t produce a metabolic acidosis.”

— Dr. Dominic D’Agostino

“Once we printed the NLRP3, I bought requests from Genentech and varied pharmaceutical firms to go there and provides a chat on the mechanism so they might drugify. And I might throw up an enormous circulation chart of all these mechanisms, and I feel they’d get pissed off. And it was like, ‘Effectively, inform us the mechanism so we are able to make a drug out of this.’”

— Dr. Dominic D’Agostino

“I went on a trip the place I forgot melatonin and I slept like a child most likely as a result of I used to be up each morning. The solar is the final word circadian synchronizer. I bought off of melatonin to test my endogenous melatonin, and there was no suppression.”

— Dr. Dominic D’Agostino

“So we went to those blue zones and so they simply, at night time after their dinner, the males will do a shot of alcohol, normally wine, however generally ouzo and so they’re all of their nineties and a whole bunch, they’re within the blue zone. So it’s a common attribute.”

— Dr. Dominic D’Agostino

Wish to hear the final time Dom was on the present? Hearken to our earlier dialog wherein we mentioned illness prevention, longevity, most cancers, ketogenic weight loss program mastery, the detoxifying results of ketosis on pre-cancerous cells, how one can jumpstart day by day ketogenic cycles, “cheat” meals, and rather more.



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